Multi-scale computational modeling of developmental biology

Multi-scale computational modeling of developmental biology

MOTIVATION Normal development of multicellular organisms is regulated by a highly complex process in which a set of precursor cells proliferate, differentiate and move, forming over time a functioning tissue. To handle their complexity, developmental systems can be studied over distinct scales. The dynamics of each scale is determined by the collective activity of entities at the scale below it...

Modeling Adaptive Multi-Agent Systems Inspired by Developmental Biology

Biology meets physics: Reductionism and multi-scale modeling of morphogenesis.

A common reductionist assumption is that macro-scale behaviors can be described "bottom-up" if only sufficient details about lower-scale processes are available. The view that an "ideal" or "fundamental" physics would be sufficient to explain all macro-scale phenomena has been met with criticism from philosophers of biology. Specifically, scholars have pointed to the impossibility of deducing b...

Computational Models for Integrative and Developmental Biology

• Initial Version: march 2002. This report is also a tutorial chapter of the proceedings of the workshop " Modélisation et simulation de processus biologiques dans le contexte de la gnomique " , 17-21 mars 2002, Autran, France.

An Adaptive Multi - Scale Computational Method for Modeling

In this dissertation a coupled multi-scale computational model for simulating nonlinear deformation processes in crystalline metals at finite temperatures is developed. The computational model uses the finite element method to model the coarse scale response of the material. The constitutive response in the finite element will be modeled through interatomic potentials acting on the underlying h...